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SISSI-Bio, a brief introduction
 

SISSI-Bio has been primarily conceived and consistently upgraded over the years for providing state of the art tools and expertise in the field of Life Sciences. Up to 2020, the majority of the SISSI-Bio users, both considering IR synchrotron radiation and off-line, belonged to the Life Science domain, a field of research very topical and in constant evolution. In the recent years, thanks also to the latest instrumental upgrades, a notable spiking of experiments in ecology and environmental sciences, soft and green materials, cultural heritage and paleo-archeological as well as biophysics fields has been recorded.

Here in the following, an overview of the most relevant studies. The complete list of SISSI-Bio publications can be found at https://scholar.google.com/citations?hl=en&user=W5ylCjsAAAAJ&view_op=list_works
 

Life Sciences at SISSI-Bio
 

The potentialities of infrared vibrational techniques in Life Science are constantly increasing and evolving, in terms of dedicated instrumentation, sampling approaches and analytical tools. Infrared bio-spectroscopy relies on the ability of the technique to probe the vibrational modes of both small and large biomolecules, and to translate the chemical details contained in an IR spectrum into information useful for purposes such as disease screening, diagnosis, prognosis and many others. Infrared hyperspectral histology and cytology are nowadays gold standard in the field of Life Science research.










TOC Alkaptonuria
Figure on the left: Cover page of Analytical Chemistry journal, for the paper: Live-Cell Synchrotron-Based FTIR Evaluation of Metabolic Compounds in Brain Glioblastoma Cell Lines after Riluzole Treatment, by T. Ducic et al., Analytical Chemistry 2022, 94, 4, 1932-1940

Hyerspectral Histology

The diagnosis and study of many diseases relies nowadays on histopathology, an optical microscopy approach where the analysis of the patient biopsies, colored by staining, is made by the pathologists. The demand for more objective and quantitative tools for tumor grading, for example, boosted the field of infrared hyperspectral histology. As a matter of fact, infrared analysis provides qualitative and quantitative indications on the tissue’s composition in terms of macromolecular constituents, variations on the phenotype, and on events such as protein fibrillation and aggregation, cellular apoptosis, lipid peroxidation etc.

Cancer research, ultrarare diseases, human and animal fertility studies are among the areas of interest od SISSI-Bio user community. Some exemplative are listed below.Lorem Ipsum is simply dummy text of the printing and typesetting industry.

 

Retrieve articles
DOIs: 10.1002/jbio.201960071, 10.1111/j.1440-1681.2011.05618.x, 10.1038/srep12129, 10.1016/j.bbagen.2017.02.008, 10.1016/j.fertnstert.2013.09.012


Hyperspectral Cytology
 


Hyerspectral Histology

The diagnosis and study of many diseases relies nowadays on histopathology, an optical microscopy approach where the analysis of the patient biopsies, colored by staining, is made by the pathologists. The demand for more objective and quantitative tools for tumor grading, for example, boosted the field of infrared hyperspectral histology. As a matter of fact, infrared analysis provides qualitative and quantitative indications on the tissue’s composition in terms of macromolecular constituents, variations on the phenotype, and on events such as protein fibrillation and aggregation, cellular apoptosis, lipid peroxidation etc.

 Cancer research, ultrarare diseases, human and animal fertility studies are among the areas of interest od SISSI-Bio user community. Some exemplative are listed below.Lorem Ipsum is simply dummy text of the printing and typesetting industry.

 

Retrieve articles
DOIs: 10.1002/jbio.201960071, 10.1111/j.1440-1681.2011.05618.x, 10.1038/srep12129, 10.1016/j.bbagen.2017.02.008, 10.1016/j.fertnstert.2013.09.012
Last Updated on Wednesday, 05 February 2025 11:14